CRIM1
Function
May play a role in CNS development by interacting with growth factors implicated in motor neuron differentiation and survival. May play a role in capillary formation and maintenance during angiogenesis. Modulates BMP activity by affecting its processing and delivery to the cell surface.
Post-translational modifications
N-glycosylated.
Tissue Specificity
Expressed in pancreas, kidney, skeletal muscle, lung, placenta, brain, heart, spleen, liver and small intestine. Expressed in blood vessels (at protein level).
Cellular localization
- Processed cysteine-rich motor neuron 1 protein
- Secreted
- Cell membrane
- Single-pass type I membrane protein
Alternative names
S52, UNQ1886/PRO4330, CRIM1, Cysteine-rich motor neuron 1 protein, CRIM-1, Cysteine-rich repeat-containing protein S52