CRLF2

The WSXWS motif appears to be necessary for proper protein folding and thereby efficient intracellular transport and cell-surface receptor binding.

The box 1 motif is important for association with JAKs.

Receptor for thymic stromal lymphopoietin (TSLP). Forms a functional complex with TSLP and IL7R which is capable of stimulating cell proliferation through activation of STAT3 and STAT5. Also activates JAK2 (By similarity). Implicated in the development of the hematopoietic system.

Belongs to the type I cytokine receptor family. Type 5 subfamily.

Expressed in heart, skeletal muscle, kidney and adult and fetal liver. Primarily expressed in dendrites and monocytes. Weakly expressed in T-cells.

• Isoform 1
• Cell membrane
• Single-pass type I membrane protein
• Isoform 2
• Secreted

CRL2, ILXR, TSLPR, CRLF2, Cytokine receptor-like factor 2, Cytokine receptor-like 2, IL-XR, Thymic stromal lymphopoietin protein receptor, TSLP receptor

• entrezGene:64109
• omim:300357
• omim:400023
• swissprot:Q9HC73

Proteins

Immuno-oncology

42013Da