CRLF3
Function
May play a role in the negative regulation of cell cycle progression.
Sequence Similarities
Belongs to the cytokine receptor-like factor 3 family.
Tissue Specificity
Expressed in several embryonic and adult tissues, including adult and fetal brain, liver, spleen and pancreas. Expressed in adult, but not fetal kidney. Expressed in skin and squamous cell carcinoma (SCC) and in several other cancer types. Also detected in lesion actinic keratosis (AK).
Cellular localization
- Cytoplasm
- The EGFP- and MYC-tagged protein has been shown to be cytoplasmic.
Alternative names
CREME9, CRLM9, CYTOR4, P48, CRLF3, Cytokine receptor-like factor 3, Cytokine receptor-like molecule 9, Cytokine receptor-related protein 4, Type I cytokine receptor-like factor p48, CREME-9