Crp

Function

Displays several functions associated with host defense: it promotes agglutination, bacterial capsular swelling, phagocytosis and complement fixation through its calcium-dependent binding to phosphorylcholine. Can interact with DNA and histones and may scavenge nuclear material released from damaged circulating cells (By similarity).

Post-translational modifications

The last two cysteines are involved either in interchain disulfide bonds or in an intrachain bond.

Sequence Similarities

Belongs to the pentraxin family.

Tissue Specificity

Found in plasma.

Cellular localization

• Secreted

Alternative names

Ptx1, Crp, C-reactive protein

Database links

swissprot:P48199 entrezGene:25419

Other research areas

• Cardiovascular
• Neuroscience