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C Reactive Protein

Function

Displays several functions associated with host defense: it promotes agglutination, bacterial capsular swelling, phagocytosis and complement fixation through its calcium-dependent binding to phosphorylcholine. Can interact with DNA and histones and may scavenge nuclear material released from damaged circulating cells (By similarity).

Post-translational modifications

The last two cysteines are involved either in interchain disulfide bonds or in an intrachain bond.

Sequence similarities

Belongs to the pentraxin family.

Tissue specificity

Found in plasma.

Cellular localization

  • Secreted

Alternative names

  • C-reactive protein
  • Crp
  • Ptx1

Target type

Proteins

Primary research area

Immunology & Infectious Disease

Other research areas

  • Cardiovascular
  • Neuroscience

Molecular weight

25468Da