CSAD
Function
Catalyzes the decarboxylation of L-aspartate, 3-sulfino-L-alanine (cysteine sulfinic acid), and L-cysteate to beta-alanine, hypotaurine and taurine, respectively. The preferred substrate is 3-sulfino-L-alanine. Does not exhibit any decarboxylation activity toward glutamate.
Pathway
Organosulfur biosynthesis; taurine biosynthesis; hypotaurine from L-cysteine: step 2/2.
Sequence Similarities
Belongs to the group II decarboxylase family.
Tissue Specificity
Expressed in liver and brain. Also expressed in both astrocytes and neurons, but lower levels are expressed in astrocytes.
Alternative names
CSD, CSAD, Cysteine sulfinic acid decarboxylase, Aspartate 1-decarboxylase, Cysteine-sulfinate decarboxylase, Sulfinoalanine decarboxylase