CSDE1/NRU

Function

RNA-binding protein involved in translationally coupled mRNA turnover (PubMed:11051545, PubMed:15314026). Implicated with other RNA-binding proteins in the cytoplasmic deadenylation/translational and decay interplay of the FOS mRNA mediated by the major coding-region determinant of instability (mCRD) domain (PubMed:11051545, PubMed:15314026). Required for efficient formation of stress granules (PubMed:29395067).

(Microbial infection) Required for internal initiation of translation of human rhinovirus RNA.

Cellular localization

• Cytoplasm
• Cytoplasm
• Stress granule
• Cytoplasm
• P-body

Alternative names

• Cold shock domain-containing protein E1
• N-ras upstream gene protein
• Protein UNR
• D1S155E
• UNR
• NRU
• KIAA0885
• CSDE1

Database links

• entrezGene:7812
• omim:191510
• swissprot:O75534

Target type

Proteins

Molecular weight

88885Da