Csf1

Function

Cytokine that plays an essential role in the regulation of survival, proliferation and differentiation of hematopoietic precursor cells, especially mononuclear phagocytes, such as macrophages and monocytes. Promotes the release of pro-inflammatory chemokines, and thereby plays an important role in innate immunity and in inflammatory processes. Plays an important role in the regulation of osteoclast proliferation and differentiation, the regulation of bone resorption, and is required for normal bone development. Required for normal male and female fertility. Promotes reorganization of the actin cytoskeleton, regulates formation of membrane ruffles, cell adhesion and cell migration. Plays a role in lipoprotein clearance (By similarity).

Involvement in disease

A defect in Csf1 is the cause of the toothless phenotype (tl). Toothless rats display osteoclastopenia, severe osteopetrosis, and dystrophic growth plates.

Post-translational modifications

N-glycosylated.

O-glycosylated; contains chondroitin sulfate.

Cellular localization

• Cell membrane
• Single-pass type I membrane protein
• Processed macrophage colony-stimulating factor 1
• Secreted
• Extracellular space

Alternative names

Csfm, Csf1, Macrophage colony-stimulating factor 1, CSF-1, MCSF, Proteoglycan macrophage colony-stimulating factor, PG-M-CSF

Database links

swissprot:Q8JZQ0 entrezGene:78965

Other research areas

• Immunology & Infectious Disease