CSF2
GeneName
CSF2
Summary
CSF2, also known as GM-CSF or granulocyte macrophage colony-stimulating factor, is a 16 kDa cytokine that is secreted into the extracellular space. It plays a pivotal role in the regulation of immune responses by promoting the proliferation and differentiation of myeloid cells, including granulocytes and macrophages. CSF2 binds to its specific receptor, initiating signalling pathways such as JAK-STAT, which are crucial for various biological processes including dendritic cell differentiation and immune response modulation. It is expressed in various tissues and is involved in numerous cellular responses to stimuli such as lipopolysaccharide.
Importance
CSF2 is relevant to: - Immune system regulation, particularly in the differentiation and activation of macrophages and neutrophils, which are essential for innate immunity - Inflammatory responses and tissue repair, as it influences cell migration and proliferation - Cancer research, given its role in the tumour microenvironment and potential implications in cancer therapies - Autoimmune diseases, where dysregulation of CSF2 can contribute to pathogenesis - Research on placental development and function due to its involvement in embryonic development processes
Top Products
For researchers investigating CSF2, we highly recommend the top-selling recombinant antibody, Anti-GM-CSF antibody [EPR25991-223] (ab300495). This antibody has been validated for use in Western blotting (WB) and immunoprecipitation (IP), making it a versatile tool for your experiments. With 6 citations, it demonstrates a growing recognition in the research community. The recombinant nature of this antibody ensures batch-to-batch consistency, providing reliable results for your studies on CSF2. The Recombinant human GM-CSF protein (Active) ELISA Kit (ab259376) is an excellent option for researchers looking to measure CSF2 in their experiments.
Abcam Product Citation Summary
The data indicates that the Abcam antibody ab174448 was consistently used to measure CSF2 levels in human platelets and neutrophils. This research context focuses on the role of neutrophil-DNA release, highlighting the importance of CSF2 in immune responses.
Abcam Product Citation Table
Function
Cytokine that stimulates the growth and differentiation of hematopoietic precursor cells from various lineages, including granulocytes, macrophages, eosinophils and erythrocytes.
Sequence Similarities
Belongs to the GM-CSF family.
Cellular localization
- Secreted
Alternative names
GMCSF, CSF2, Granulocyte-macrophage colony-stimulating factor, GM-CSF, Colony-stimulating factor, Molgramostin, Sargramostim, CSF
Database links
Other research areas
- Immunology & Infectious Disease
- Neuroscience