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Domain

The WSXWS motif appears to be necessary for proper protein folding and thereby efficient intracellular transport and cell-surface receptor binding.

The box 1 motif is required for JAK interaction and/or activation.

Function

High affinity receptor for interleukin-3, interleukin-5 and granulocyte-macrophage colony-stimulating factor.

Post-translational modifications

May be phosphorylated by LYN.

Sequence similarities

Belongs to the type I cytokine receptor family. Type 4 subfamily.

Cellular localization

  • Membrane
  • Single-pass type I membrane protein

Alternative names

CD131, Aic2b, Csf2rb1, Il3rb1, Csf2rb, Cytokine receptor common subunit beta, GM-CSF/IL-3/IL-5 receptor common beta subunit

Target type

Proteins

Primary research area

Immunology & Infectious Disease

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