Csf2rb
Domain
The WSXWS motif appears to be necessary for proper protein folding and thereby efficient intracellular transport and cell-surface receptor binding.
The box 1 motif is required for JAK interaction and/or activation.
Function
High affinity receptor for interleukin-3, interleukin-5 and granulocyte-macrophage colony-stimulating factor.
Post-translational modifications
May be phosphorylated by LYN.
Sequence Similarities
Belongs to the type I cytokine receptor family. Type 4 subfamily.
Cellular localization
- Membrane
- Single-pass type I membrane protein
Alternative names
CD131, Aic2b, Csf2rb1, Il3rb1, Csf2rb, Cytokine receptor common subunit beta, GM-CSF/IL-3/IL-5 receptor common beta subunit