CSF3
GeneName
CSF3
Summary
CSF3, also known as granulocyte colony stimulating factor (G-CSF), is a 22 kDa cytokine that plays a vital role in the regulation of granulocyte production and differentiation in the bone marrow. It is secreted into the extracellular space and can be found in various cellular compartments, including endocytic vesicles and lysosomal lumen. CSF3 binds to its specific receptor, promoting a range of cellular responses such as granulocyte differentiation and activation of immune responses. It is involved in cytokine-mediated signalling pathways and influences actin filament dynamics, which are essential for cell movement and function.
Importance
CSF3 is relevant to: - The treatment of neutropenia, particularly in patients undergoing chemotherapy, as it stimulates the production of neutrophils. - Immune responses during infections, given its role in promoting granulocyte differentiation and function. - The understanding of inflammatory processes, since it is involved in cytokine signalling and response to lipopolysaccharide. - Research into myeloid cell development and function, contributing to insights into various haematological disorders.
Top Products
For researchers investigating CSF3, we recommend two excellent primary antibodies that cater to a variety of applications. The first is the well-cited polyclonal antibody, Anti-G-CSF antibody (ab9691), which has garnered 12 citations and is particularly effective in Western blotting (WB) and ELISA. This product is a trusted choice for those looking to study G-CSF in detail. Additionally, we offer the recombinant antibody, Anti-G-CSF antibody [EPR3203(N)(B)] (ab181053), which has an impressive 17 citations. This recombinant antibody is validated for use in multiple applications, including WB, flow cytometry (FC), immunocytochemistry (ICC), and immunoprecipitation (IP). Its batch-to-batch consistency makes it an ideal option for researchers seeking reliable and reproducible results in their studies of CSF3. The Human G-CSF ELISA Kit, Fluorescent (ab229430) is an excellent option for researchers looking to measure CSF3 levels in their samples.
Abcam Product Citation Summary
The data indicates that the CSF3 antibody (ab181053) has been effectively used in Western blotting to study its role in hematopoietic injury and G-CSF-mediated signalling in mouse tissues, specifically spleen and bone marrow nucleated cells. This suggests a significant involvement of CSF3 in these biological contexts.
Abcam Product Citation Table
Function
Granulocyte/macrophage colony-stimulating factors are cytokines that act in hematopoiesis by controlling the production, differentiation, and function of 2 related white cell populations of the blood, the granulocytes and the monocytes-macrophages. This CSF induces granulocytes.
Post-translational modifications
O-glycan consists of Gal-GalNAc disaccharide which can be modified with up to two sialic acid residues (done in recombinantly expressed G-CSF from CHO cells).
Sequence Similarities
Belongs to the IL-6 superfamily.
Cellular localization
- Secreted
Alternative names
C17orf33, GCSF, CSF3, Granulocyte colony-stimulating factor, G-CSF, Pluripoietin
Database links
swissprot:P09919 omim:138970 entrezGene:1440
Other research areas
- Immunology & Infectious Disease