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Function

Granulocyte/macrophage colony-stimulating factors are cytokines that act in hematopoiesis by controlling the production, differentiation, and function of 2 related white cell populations of the blood, the granulocytes and the monocytes-macrophages. This CSF induces granulocytes.

Post-translational modifications

O-glycan consists of Gal-GalNAc disaccharide which can be modified with up to two sialic acid residues (done in recombinantly expressed G-CSF from CHO cells).

Sequence similarities

Belongs to the IL-6 superfamily.

Cellular localization

  • Secreted

Alternative names

C17orf33, GCSF, CSF3, Granulocyte colony-stimulating factor, G-CSF, Pluripoietin

Target type

Proteins

Primary research area

Immuno-oncology

Other research areas

  • Immunology & Infectious Disease

Molecular weight

22293Da

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