CSPG5
Developmental stage
Expressed in brain of 3 months, 5 and 10-year-old individuals.
Function
May function as a growth and differentiation factor involved in neuritogenesis. May induce ERBB3 activation.
Post-translational modifications
N-glycosylated.
O-glycosylated; contains chondroitin sulfate glycans (PubMed:25326458). Part-time proteoglycan, expressed in part as a proteoglycan exhibiting chondroitin sulfate glycans and in part as a non-proteoglycan form (By similarity). The relative amount of both forms depends on tissues and tissue maturation (By similarity).
Phosphorylated; in intracellular and extracellular parts.
Tissue Specificity
Detected in cerebrospinal fluid (at protein level) (PubMed:25326458). Detected in urine (at protein level) (PubMed:37453717). Expressed in brain (at protein level) (PubMed:9950058).
Cellular localization
- Cell membrane
- Single-pass type I membrane protein
- Synaptic cell membrane
- Single-pass type I membrane protein
- Endoplasmic reticulum membrane
- Single-pass type I membrane protein
- Golgi apparatus membrane
- Single-pass type I membrane protein
- Cell surface
- Secreted
- In neurons, localizes to synaptic junctions. Also detected in the endoplasmic reticulum and the Golgi. Partially enriched in lipid rafts.
Alternative names
CALEB, NGC, CSPG5, Chondroitin sulfate proteoglycan 5, Acidic leucine-rich EGF-like domain-containing brain protein, Neuroglycan C