CT55
Function
Plays a role in spermatogenesis, possibly acting in the regulation of the autophagy pathway.
Involvement in disease
Spermatogenic failure, X-linked, 7
SPGFX7
A male infertility disorder characterized by a significant reduction in sperm count and motility, and aberrant sperm morphology with abnormalities of the head and flagella. Patient sperm show insufficient individualization, excessive residual cytoplasm, and defects in acrosome development.
None
The disease is caused by variants affecting the gene represented in this entry.
Tissue Specificity
Testis-specific (PubMed:15499386). Expressed in spermatozoa (at protein level) (PubMed:36481789).
Cellular localization
- Cytoplasm
- Cytoplasmic vesicle
- Secretory vesicle
- Acrosome
- Cell projection
- Cilium
- Flagellum
- Mainly observed in the cytoplasm of spermatocyte and spermatogonia, and also found in acrosome or flagellum in early and late spermatids.
Alternative names
CXorf48, CT55, Cancer/testis antigen 55, Tumor antigen BJ-HCC-20