CTDSPL
Function
Recruited by REST to neuronal genes that contain RE-1 elements, leading to neuronal gene silencing in non-neuronal cells (By similarity). Preferentially catalyzes the dephosphorylation of 'Ser-5' within the tandem 7 residue repeats in the C-terminal domain (CTD) of the largest RNA polymerase II subunit POLR2A. Negatively regulates RNA polymerase II transcription, possibly by controlling the transition from initiation/capping to processive transcript elongation.
Tissue Specificity
Expression is restricted to non-neuronal tissues.
Cellular localization
- Nucleus
Alternative names
C3orf8, NIF1, NIFL, SCP3, YA22, CTDSPL, CTD small phosphatase-like protein, CTDSP-like, Carboxy-terminal domain RNA polymerase II polypeptide A small phosphatase 3, NIF-like protein, Nuclear LIM interactor-interacting factor 1, Protein YA22, RBSP3, Small C-terminal domain phosphatase 3, NLI-interacting factor 1, hYA22, Small CTD phosphatase 3