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Function

Induces cardiac myocyte hypertrophy in vitro. Binds to and activates the ILST/gp130 receptor.

Sequence similarities

Belongs to the IL-6 superfamily.

Tissue specificity

Highly expressed in heart, skeletal muscle, liver, lung and kidney. Lower levels in testis and brain. No expression in spleen.

Cellular localization

  • Secreted

Alternative names

Cardiotrophin-1, CT-1, Ctf1

Target type

Proteins

Primary research area

Cardiovascular

Molecular weight

21509Da