CTHRC1

May act as a negative regulator of collagen matrix deposition.

Barrett esophagus

BE

A condition characterized by a metaplastic change in which normal esophageal squamous epithelium is replaced by a columnar and intestinal-type epithelium. Patients with Barrett esophagus have an increased risk of esophageal adenocarcinoma. The main cause of Barrett esophagus is gastroesophageal reflux. The retrograde movement of acid and bile salts from the stomach into the esophagus causes prolonged injury to the esophageal epithelium and induces chronic esophagitis, which in turn is believed to trigger the pathologic changes.

None

Disease susceptibility is associated with variants affecting the gene represented in this entry.

N-glycosylated.

Isoform 1 is expressed in calcified atherosclerotic plaque and chondrocyte-like cells.

• Secreted
• Extracellular space
• Extracellular matrix

UNQ762/PRO1550, CTHRC1, Collagen triple helix repeat-containing protein 1

• entrezGene:115908
• omim:610635
• swissprot:Q96CG8

Proteins

Oncology

26224Da