Ctla4

Function

Inhibitory receptor acting as a major negative regulator of T-cell responses. The affinity of CTLA4 for its natural B7 family ligands, CD80 and CD86, is considerably stronger than the affinity of their cognate stimulatory coreceptor CD28.

Post-translational modifications

N-glycosylation is important for dimerization.

Phosphorylation at Tyr-201 prevents binding to the AP-2 adapter complex, blocks endocytosis, and leads to retention of CTLA4 on the cell surface.

Tissue Specificity

Widely expressed with highest levels in lymphoid tissues.

Cellular localization

• Cell membrane
• Single-pass type I membrane protein
• Exists primarily an intracellular antigen whose surface expression is tightly regulated by restricted trafficking to the cell surface and rapid internalization.

Alternative names

CD152, Cd152, Ctla4, Cytotoxic T-lymphocyte protein 4, Cytotoxic T-lymphocyte-associated antigen 4, CTLA-4

Database links

swissprot:P09793 entrezGene:12477 entrezGene:100505288

Other research areas

• Immunology & Infectious Disease