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CTNNA3

Function

May be involved in formation of stretch-resistant cell-cell adhesion complexes.

Involvement in disease

Arrhythmogenic right ventricular dysplasia, familial, 13

ARVD13

A congenital heart disease characterized by infiltration of adipose and fibrous tissue into the right ventricle and loss of myocardial cells, resulting in ventricular and supraventricular arrhythmias.

None

The disease is caused by variants affecting the gene represented in this entry.

Sequence similarities

Belongs to the vinculin/alpha-catenin family.

Tissue specificity

Predominantly expressed in heart and testis. Expressed at lower levels in brain, kidney, liver and skeletal muscle.

Cellular localization

  • Cytoplasm
  • Cytoskeleton
  • Localizes to intercalated disks of cardiomyocytes and in peritubular myoid cells of testis, and colocalizes with CTNNA1 and CTNNA2.

Alternative names

  • Catenin alpha-3
  • Alpha T-catenin
  • Cadherin-associated protein
  • CTNNA3

Target type

Proteins

Molecular weight

99809Da