CTRC
Function
Regulates activation and degradation of trypsinogens and procarboxypeptidases by targeting specific cleavage sites within their zymogen precursors. Has chymotrypsin-type protease activity and hypocalcemic activity.
Involvement in disease
Pancreatitis, hereditary
PCTT
A disease characterized by pancreas inflammation, permanent destruction of the pancreatic parenchyma, maldigestion, and severe abdominal pain attacks.
None
Disease susceptibility is associated with variants affecting the gene represented in this entry. Loss-of-function CTRC variants predispose to pancreatitis by diminishing its protective trypsin-degrading activity (PubMed:18059268). They cause loss of function by one or more of three mechanisms: reduced secretion, catalytic defect and increased degradation by trypsin (PubMed:22942235).
Sequence Similarities
Belongs to the peptidase S1 family. Elastase subfamily.
Tissue Specificity
Pancreas.
Alternative names
CLCR, CTRC, Chymotrypsin-C, Caldecrin