CTSK
GeneName
CTSK
Summary
CTSK, also known as cathepsin K or cathepsin X, is a 37 kDa cysteine protease predominantly expressed in osteoclasts, where it plays a pivotal role in bone resorption and the degradation of collagen and other extracellular matrix components. This enzyme is localised to various cellular compartments, including the lysosome, endolysosome lumen, and extracellular space, facilitating its function in proteolytic processes. CTSK is involved in collagen catabolism and extracellular matrix disassembly, contributing to both normal bone remodelling and pathological conditions such as osteoporosis.
Importance
CTSK is relevant to: - Osteoporosis and other bone-related diseases due to its central role in bone resorption and collagen degradation - Cartilage development and disorders, as it negatively regulates cartilage formation - Tissue remodelling processes in various physiological and pathological contexts - Potential therapeutic target for modulating bone metabolism and treating conditions associated with excessive bone resorption
Top Products
For researchers investigating CTSK, we recommend two excellent primary antibodies. The first is the well-cited Anti-Cathepsin K antibody [3F9] (ab37259), which has garnered 43 citations and is highly regarded for its performance in Western blotting (WB), immunohistochemistry (IHC), and flow cytometry (FC). This antibody is a reliable choice for those looking to study CTSK in various applications. Additionally, we offer the recombinant antibody, Anti-Cathepsin K antibody [EP9403] (ab187647). This product has been validated for use in WB and IHC, making it a versatile option for researchers who require the consistency that recombinant antibodies provide. With 32 citations, it is also gaining recognition in the research community. Together, these antibodies provide robust tools for studying CTSK effectively.
Abcam Product Citation Summary
The data indicates that CTSK is being studied in the context of osteoclastogenesis and its expression in human bone marrow-derived macrophages. The use of Western blotting suggests a focus on protein expression levels in these studies.
Abcam Product Citation Table
Function
Thiol protease involved in osteoclastic bone resorption and may participate partially in the disorder of bone remodeling. Displays potent endoprotease activity against fibrinogen at acid pH. May play an important role in extracellular matrix degradation. Involved in the release of thyroid hormone thyroxine (T4) by limited proteolysis of TG/thyroglobulin in the thyroid follicle lumen (PubMed:11082042).
Involvement in disease
Pycnodysostosis
PKND
A rare autosomal recessive bone disorder characterized by deformity of the skull, maxilla and phalanges, osteosclerosis, and fragility of bone.
None
The disease is caused by variants affecting the gene represented in this entry.
Sequence Similarities
Belongs to the peptidase C1 family.
Tissue Specificity
Predominantly expressed in osteoclasts (bones) (PubMed:7805878). Expressed in thyroid epithelial cells (PubMed:11082042).
Cellular localization
- Lysosome
- Secreted
- Apical cell membrane
- Peripheral membrane protein
- Extracellular side
- Localizes to the lumen of thyroid follicles and to the apical membrane of thyroid epithelial cells.
Alternative names
CTSO, CTSO2, CTSK, Cathepsin K, Cathepsin O, Cathepsin O2, Cathepsin X