CTSS

Function

Thiol protease. Key protease responsible for the removal of the invariant chain from MHC class II molecules and MHC class II antigen presentation (PubMed:30612035). The bond-specificity of this proteinase is in part similar to the specificities of cathepsin L.

Sequence similarities

Belongs to the peptidase C1 family.

Cellular localization

• Lysosome
• Secreted
• Cytoplasmic vesicle
• Phagosome

Alternative names

• Cathepsin S
• CTSS

Database links

• entrezGene:1520
• omim:116845
• swissprot:P25774

Target type

Proteins

Primary research area

Immunology & Infectious Disease

Molecular weight

37496Da