Cuzd1
Developmental stage
First detected in uterus 6 days prior to birth, increases daily to reach maximum levels 3 days before birth, abruptly decreases during the last 3 days of pregnancy and is almost undetectable by the first day after birth.
Function
Localized to zymogen granules, where it functions in trypsinogen activation (PubMed:12401800). May indirectly regulate cell motility, cell-cell and cell/extracellular matrix interactions (By similarity).
Tissue Specificity
Highly expressed in pancreatic acinar cells. Also expressed in epithelium of the uterus during late pregnancy but not detected in non-pregnant uterus or in a variety of other adult and fetal tissues.
Cellular localization
- Zymogen granule membrane
- Single-pass type I membrane protein
Alternative names
Itmap1, Cuzd1, CUB and zona pellucida-like domain-containing protein 1, CUB and ZP domain-containing protein 1, Integral membrane-associated protein 1