Cxcl1

Function

Has chemotactic activity for neutrophils. Contributes to neutrophil activation during inflammation (By similarity). Hematoregulatory chemokine, which, in vitro, suppresses hematopoietic progenitor cell proliferation. KC(5-72) shows a highly enhanced hematopoietic activity.

Post-translational modifications

The N-terminal processed form KC(5-72) is produced by proteolytic cleavage after secretion from bone marrow stromal cells.

Sequence Similarities

Belongs to the intercrine alpha (chemokine CxC) family.

Cellular localization

• Secreted

Alternative names

Gro, Gro1, Mgsa, Scyb1, Cxcl1, Growth-regulated alpha protein, C-X-C motif chemokine 1, Platelet-derived growth factor-inducible protein KC, Secretory protein N51

Database links

swissprot:P12850 entrezGene:14825

Other research areas

• Immuno-oncology
• Neuroscience