Cxcl11

Function

Chemotactic for interleukin-activated T-cells but not unstimulated T-cells, neutrophils or monocytes. Induces calcium release in activated T-cells. Binds to CXCR3. May play an important role in CNS diseases which involve T-cell recruitment. May play a role in skin immune responses (By similarity).

Sequence Similarities

Belongs to the intercrine alpha (chemokine CxC) family.

Cellular localization

• Secreted

Alternative names

Scyb11, Cxcl11, C-X-C motif chemokine 11, Interferon-inducible T-cell alpha chemoattractant, Small-inducible cytokine B11, I-TAC

Database links

swissprot:Q9JHH5 entrezGene:56066

Other research areas

• Immuno-oncology