CXCL14
Domain
The destruction box (D-box) acts as a recognition signal for degradation via the ubiquitin-proteasome pathway.
Function
Potent chemoattractant for neutrophils, and weaker for dendritic cells. Not chemotactic for T-cells, B-cells, monocytes, natural killer cells or granulocytes. Does not inhibit proliferation of myeloid progenitors in colony formation assays.
Post-translational modifications
Ubiquitinated, followed by degradation by the proteasome.
Sequence Similarities
Belongs to the intercrine alpha (chemokine CxC) family.
Tissue Specificity
Expressed in heart, brain, placenta, lung, liver, skeletal muscle, kidney and pancreas. Highly expressed in normal tissue without inflammatory stimuli and infrequently expressed in cancer cell lines. Weakly expressed in monocyte-derived dendritic cells. Not detected in lung or unstimulated peripheral blood lymphocytes.
Cellular localization
- Secreted
Alternative names
MIP2G, NJAC, SCYB14, PSEC0212, UNQ240/PRO273, CXCL14, C-X-C motif chemokine 14, Chemokine BRAK, MIP-2G, Small-inducible cytokine B14