Cxcl16
Function
Induces a strong chemotactic response. Induces calcium mobilization. Binds to CXCR6/Bonzo. Also acts as a scavenger receptor on macrophages, which specifically binds to OxLDL (oxidized low density lipoprotein), suggesting that it may be involved in pathophysiology such as atherogenesis.
Post-translational modifications
Glycosylated.
Sequence Similarities
Belongs to the intercrine alpha (chemokine CxC) family.
Tissue Specificity
Widely expressed. Not detected in purified B- and T-cells.
Cellular localization
- Membrane
- Single-pass type I membrane protein
Alternative names
Srpsox, Cxcl16, C-X-C motif chemokine 16, Scavenger receptor for phosphatidylserine and oxidized low density lipoprotein, Small-inducible cytokine B16, Transmembrane chemokine CXCL16, SR-PSOX