Cxcl16

Function

Acts as a scavenger receptor on macrophages, which specifically binds to OxLDL (oxidized low density lipoprotein), suggesting that it may be involved in pathophysiology such as atherogenesis (By similarity). Induces a strong chemotactic response. Induces calcium mobilization. Binds to CXCR6/Bonzo.

Post-translational modifications

Glycosylated.

Sequence similarities

Belongs to the intercrine alpha (chemokine CxC) family.

Tissue specificity

Expressed in T-cell areas. Expressed in spleen, lymph nodes, lung, kidney, small intestine and thymus. Weak expression in heart and liver and no expression in brain and bone marrow.

Cellular localization

• Cell membrane
• Single-pass type I membrane protein
• Secreted
• Also exists as a soluble form.

Alternative names

• SCYB16
• SRPSOX
• UNQ2759/PRO6714
• SCYB16
• CXCL16
• UNQ2759/PRO6714
• SRPSOX
• C-X-C motif chemokine 16
• Scavenger receptor for phosphatidylserine and oxidized low density lipoprotein
• Small-inducible cytokine B16
• Transmembrane chemokine CXCL16
• SR-PSOX

Database links

• entrezGene:58191
• omim:605398
• swissprot:Q9H2A7

Target type

Proteins

Primary research area

Immuno-oncology

Molecular weight

27579Da