CXCL17
Developmental stage
Detected in fetal lung.
Function
Chemokine that acts as a chemoattractant for monocytes, macrophages and dendritic cells (PubMed:16455961, PubMed:23115081). Plays a role in angiogenesis and possibly in the development of tumors (PubMed:16989774, PubMed:23115081). Acts as an anti-inflammatory in the stomach (PubMed:23115081). May play a role in the innate defense against infections (PubMed:17307946). Activates the C-X-C chemokine receptor GPR35 to induce a rapid and transient rise in the level of intracellular calcium ions (PubMed:25411203).
4-Cys CXCL17
Seems to exhibit much higher chemoattractant potency on monocytes and macrophages than 6-Cys CXCL17.
Post-translational modifications
Likely to undergo an endoproteolytic process to form a four-cysteine-containing mature peptide with a canonical CXC chemokine scaffold after secretion.
Sequence Similarities
Belongs to the intercrine alpha (chemokine CxC) family.
Tissue Specificity
Detected in trachea, stomach, lung and skeletal muscle. Detected in intestine and in normal and asthmatic lung (at protein level). Breast tumors showed 3- to 24-fold up-regulation.
Cellular localization
- Secreted
Alternative names
VCC1, UNQ473/PRO842, CXCL17, C-X-C motif chemokine 17, 6-Cys CXCL17, Dendritic cell and monocyte chemokine-like protein, VEGF coregulated chemokine 1, DMC