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Function

Chemotactic for human polymorphonuclear leukocytes but does not induce chemokinesis or an oxidative burst. Contributes to neutrophil activation during inflammation.

Sequence similarities

Belongs to the intercrine alpha (chemokine CxC) family.

Tissue specificity

At least expressed in the lung and trachea.

Cellular localization

  • Secreted

Alternative names

Cinc3, Mip-2, Mip2, Scyb2, Cxcl2, C-X-C motif chemokine 2, Cytokine-induced neutrophil chemoattractant 3, Macrophage inflammatory protein 2, CINC-3, MIP2

Target type

Proteins

Primary research area

Immunology & Infectious Disease

Other research areas

  • Immuno-oncology

Molecular weight

10783Da