CXCL2

Function

Produced by activated monocytes and neutrophils and expressed at sites of inflammation. Hematoregulatory chemokine, which, in vitro, suppresses hematopoietic progenitor cell proliferation. GRO-beta(5-73) shows a highly enhanced hematopoietic activity.

Post-translational modifications

The N-terminal processed form GRO-beta(5-73) is produced by proteolytic cleavage after secretion from bone marrow stromal cells.

Sequence Similarities

Belongs to the intercrine alpha (chemokine CxC) family.

Cellular localization

• Secreted

Alternative names

GRO2, GROB, MIP2A, SCYB2, CXCL2, C-X-C motif chemokine 2, Growth-regulated protein beta, Macrophage inflammatory protein 2-alpha, Gro-beta, MIP2-alpha

Database links

swissprot:P19875 entrezGene:2920 omim:139110

Other research areas

• Immuno-oncology