CXCL5
GeneName
CXCL5
Summary
CXCL5, also known as ENA-78 or LIX, is a 12 kDa chemokine that is secreted into the extracellular region and space. It plays a critical role in mediating immune responses by acting as a chemotactic factor for neutrophils, promoting their migration to sites of inflammation. CXCL5 binds to CXCR chemokine receptors and is involved in various biological processes, including cell-cell signalling, inflammatory responses, and the regulation of cell population proliferation. Its expression is often upregulated in response to lipopolysaccharide, highlighting its role in the immune response to bacterial infections.
Importance
CXCL5 is relevant to: - The recruitment of neutrophils during inflammation, which is vital for the immune response to infections and tissue injury. - The pathogenesis of inflammatory diseases, such as asthma and rheumatoid arthritis, due to its role in promoting neutrophil chemotaxis. - Cancer progression, as it may facilitate tumour growth and metastasis through its effects on the immune microenvironment. - The development of therapeutic strategies targeting chemokine signalling pathways to modulate immune responses.
Top Products
For researchers investigating CXCL5, we recommend two excellent primary antibodies that cater to different experimental needs. The first is the well-cited polyclonal antibody, Anti-CXCL5 antibody (ab9802), which has garnered 14 citations and is particularly effective for ELISA applications. This product is a trusted choice for those focusing on quantifying CXCL5 levels.In addition, we offer the recombinant antibody, Anti-CXCL5 antibody [EPR4450(2)] (ab126763), which has been validated in knockout models and is suitable for Western blotting (WB) and immunoprecipitation (IP). With 7 citations, this monoclonal antibody provides the batch-to-batch consistency that researchers often require, making it an excellent option for reliable CXCL5 detection in various applications. The Human CXCL5 ELISA Kit (ab212163) is an excellent option for researchers looking to accurately measure CXCL5 levels in their samples.
Abcam Product Citation Summary
The CXCL5 antibody (ab9802) has been utilised in studies focusing on both mouse models of DSS-induced colitis and human pancreatic ductal adenocarcinoma. This suggests its relevance in inflammatory conditions and cancer research.
Abcam Product Citation Table
Function
Involved in neutrophil activation. In vitro, ENA-78(8-78) and ENA-78(9-78) show a threefold higher chemotactic activity for neutrophil granulocytes.
Post-translational modifications
N-terminal processed forms ENA-78(8-78) and ENA-78(9-78) are produced by proteolytic cleavage after secretion from peripheral blood monocytes.
Sequence Similarities
Belongs to the intercrine alpha (chemokine CxC) family.
Cellular localization
- Secreted
Alternative names
ENA78, SCYB5, CXCL5, C-X-C motif chemokine 5, ENA-78(1-78), Epithelial-derived neutrophil-activating protein 78, Neutrophil-activating peptide ENA-78, Small-inducible cytokine B5
Database links
swissprot:P42830 omim:138965 omim:600324 swissprot:P80162 entrezGene:6374 entrezGene:6372