CXCL5

Function

May participate in the recruitment of inflammatory cells by injured or infected tissue. GCP-2(1-78) and, more potent, GCP-2(9-78) attract neutrophils and are involved in neutrophil activation.

Post-translational modifications

GCP-2(1-78) and GCP-2(9-78) are produced by proteolytic cleavage after secretion from fibroblasts and epithelial cells. GCP-2(9-78) is the most prominent form. A number of additional N-terminal (processed between pos. 41 and 48) and C-terminal (processed between pos. 118 and 132) processed forms have been identified, probably also representing intermediate states.

Sequence similarities

Belongs to the intercrine alpha (chemokine CxC) family.

Cellular localization

• Secreted

Alternative names

• C-X-C motif chemokine 5
• Cytokine LIX
• Small-inducible cytokine B5
• Scyb5
• Cxcl5

Database links

• entrezGene:20311
• swissprot:P50228
• swissprot:Q8K3I3

Target type

Proteins

Primary research area

Immuno-oncology

Molecular weight

14235Da