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CXCL8

Function

IL-8 is a chemotactic factor that attracts neutrophils, basophils, and T-cells, but not monocytes. It is also involved in neutrophil activation. It is released from several cell types in response to an inflammatory stimulus. IL-8(6-77) has a 5-10-fold higher activity on neutrophil activation, IL-8(5-77) has increased activity on neutrophil activation and IL-8(7-77) has a higher affinity to receptors CXCR1 and CXCR2 as compared to IL-8(1-77), respectively.

Post-translational modifications

Several N-terminal processed forms are produced by proteolytic cleavage after secretion from at least peripheral blood monocytes, leukcocytes and endothelial cells. In general, IL-8(1-77) is referred to as interleukin-8. IL-8(6-77) is the most promiment form.

Citrullination at Arg-27 prevents proteolysis, and dampens tissue inflammation, it also enhances leukocytosis, possibly through impaired chemokine clearance from the blood circulation.

Sequence similarities

Belongs to the intercrine alpha (chemokine CxC) family.

Cellular localization

  • Secreted

Alternative names

  • Interleukin-8
  • IL-8
  • C-X-C motif chemokine 8
  • Chemokine (C-X-C motif) ligand 8
  • Emoctakin
  • Granulocyte chemotactic protein 1
  • Monocyte-derived neutrophil chemotactic factor
  • Monocyte-derived neutrophil-activating peptide
  • Neutrophil-activating protein 1
  • Protein 3-10C
  • T-cell chemotactic factor
  • GCP-1
  • MDNCF
  • MONAP
  • NAP-1
  • IL8
  • CXCL8

Target type

Proteins

Primary research area

Immunology & Infectious Disease

Other research areas

  • Immuno-oncology
  • Neuroscience

Molecular weight

11098Da