CXCL9
GeneName
CXCL9
Summary
CXCL9, also known as MIG or CXCL-9, is a 14 kDa chemokine that is secreted and primarily found in the extracellular region and the external side of the plasma membrane. It plays a critical role in chemokine-mediated signalling and is involved in various biological processes such as immune response, inflammatory response, and chemotaxis. CXCL9 exerts its functions by binding to CXCR3 chemokine receptors, facilitating cell-cell signalling and cellular defence responses, particularly in response to viral infections and lipopolysaccharide stimulation. Its expression is often upregulated in inflamed tissues, making it a significant player in immune cell recruitment and activation.
Importance
CXCL9 is relevant to: - The recruitment and activation of immune cells, particularly in the context of viral infections and inflammatory diseases. - The regulation of neutrophil chemotaxis, which is crucial for effective immune responses. - The modulation of myoblast differentiation and fusion, highlighting its role in muscle regeneration. - The involvement in G protein-coupled receptor signalling pathways, linking it to various cellular responses and signal transduction mechanisms.
Top Products
For researchers investigating CXCL9, we recommend two excellent primary antibodies. The first is the well-cited polyclonal antibody, Anti-CXCL9 antibody (ab9720), which is particularly effective for ELISA applications and has garnered 11 citations, reflecting its reliability in the field. Additionally, we offer the recombinant antibody, Anti-CXCL9 antibody [EPR26512-118] (ab290643), which is validated for a broader range of applications, including immunohistochemistry (IHC), western blotting (WB), flow cytometry (FC), immunocytochemistry (ICC), and immunoprecipitation (IP). This recombinant product provides the batch-to-batch consistency that many researchers seek, making it an excellent choice for those studying CXCL9. With 4 citations, it is also gaining recognition in the research community. The Human CXCL9 ELISA Kit, Fluorescent (ab270891) is an excellent option for researchers looking to measure CXCL9 levels in their samples.
Abcam Product Citation Summary
The data indicates that CXCL9 is being studied in the context of human pancreatic cancer, particularly focusing on its regulation of FOXO1 expression. The use of both Western blotting and immunohistochemistry suggests a thorough investigation of CXCL9's role in this disease.
Abcam Product Citation Table
Function
Cytokine that affects the growth, movement, or activation state of cells that participate in immune and inflammatory response. Chemotactic for activated T-cells. Binds to CXCR3.
Sequence Similarities
Belongs to the intercrine alpha (chemokine CxC) family.
Cellular localization
- Secreted
Alternative names
CMK, MIG, SCYB9, CXCL9, C-X-C motif chemokine 9, Gamma-interferon-induced monokine, Monokine induced by interferon-gamma, Small-inducible cytokine B9, HuMIG
Database links
swissprot:Q07325 entrezGene:4283 omim:601704
Other research areas
- Immuno-oncology