Skip to main content

CXCR5

Function

Cytokine receptor that binds to B-lymphocyte chemoattractant (BLC). Involved in B-cell migration into B-cell follicles of spleen and Peyer patches but not into those of mesenteric or peripheral lymph nodes. May have a regulatory function in Burkitt lymphoma (BL) lymphomagenesis and/or B-cell differentiation.

Sequence similarities

Belongs to the G-protein coupled receptor 1 family.

Tissue specificity

Expression in mature B-cells and Burkitt lymphoma cells.

Cellular localization

  • Cell membrane
  • Multi-pass membrane protein

Alternative names

  • C-X-C chemokine receptor type 5
  • CXC-R5
  • CXCR-5
  • Burkitt lymphoma receptor 1
  • Monocyte-derived receptor 15
  • MDR-15
  • BLR1
  • MDR15
  • CXCR5

Target type

Proteins

Primary research area

Immunology & Infectious Disease

Other research areas

  • Immuno-oncology
  • Neuroscience

Molecular weight

41955Da