CXCR5
GeneName
CXCR5
Summary
CXCR5, also known as NLR, BLR1, or BLR-1, is a 42 kDa G protein-coupled receptor predominantly expressed on B cells and T follicular helper cells. It is localised to the plasma membrane and plays a crucial role in the immune response by mediating B cell activation and chemotaxis towards chemokines such as CXCL13. CXCR5 is essential for lymph node development and the formation of germinal centres, facilitating the migration of lymphocytes during immune responses. Its involvement in calcium-mediated signalling further underscores its importance in regulating cellular functions.
Importance
CXCR5 is relevant to: - B cell trafficking and localisation within lymphoid tissues, impacting antibody responses - Immune surveillance and the development of effective immune responses against pathogens - Autoimmune diseases, as dysregulation of CXCR5 can lead to aberrant B cell activation and tissue infiltration - Cancer immunology, particularly in the context of tumour microenvironments where CXCR5+ cells may influence tumour progression and immune evasion
Top Products
For researchers investigating CXCR5, we highly recommend the top-selling recombinant antibody, Anti-CXCR5 antibody [EPR23463-30] (ab254415). This antibody has been validated in knockout models and is suitable for a variety of applications, including flow cytometry (FC), immunohistochemistry (IHC), western blotting (WB), and immunocytochemistry (ICC). With 11 citations, it is gaining recognition in the research community for its reliability and performance. This product is an excellent choice for those seeking consistent results in their CXCR5 studies. The Anti-CXCR5 antibody [EPR23463-30] ELISA Kit (ab254415), supported by 11 citations, is an excellent option for researchers looking to accurately measure CXCR5 levels in their samples.
Abcam Product Citation Summary
The data indicates that the CXCR5 antibody (ab254415) has been utilised in immunohistochemistry studies focused on human nasopharyngeal carcinoma tissue. This suggests a potential role of CXCR5 in the pathology of this cancer type.
Abcam Product Citation Table
Function
Cytokine receptor that binds to B-lymphocyte chemoattractant (BLC). Involved in B-cell migration into B-cell follicles of spleen and Peyer patches but not into those of mesenteric or peripheral lymph nodes. May have a regulatory function in Burkitt lymphoma (BL) lymphomagenesis and/or B-cell differentiation.
Sequence Similarities
Belongs to the G-protein coupled receptor 1 family.
Tissue Specificity
Expression in mature B-cells and Burkitt lymphoma cells.
Cellular localization
- Cell membrane
- Multi-pass membrane protein
Alternative names
CD185, BLR1, MDR15, CXCR5, C-X-C chemokine receptor type 5, CXC-R5, CXCR-5, Burkitt lymphoma receptor 1, Monocyte-derived receptor 15, MDR-15
Database links
swissprot:P32302 omim:601613 entrezGene:643
Other research areas
- Immuno-oncology
- Neuroscience