CYB561A3
Function
Transmembrane reductase that uses ascorbate as an electron donor in the cytoplasm and transfers electrons across membranes to reduce iron cations Fe(3+) into Fe(2+) in the lumen of the late endosome and lysosome. Reduced iron can then be extruded from the late endosome and lysosome to the cytoplasm by divalent metal-specific transporters. It is therefore most probably involved in endosomal and lysosomal cellular iron homeostasis.
Post-translational modifications
N-glycosylated.
Cellular localization
- Late endosome membrane
- Multi-pass membrane protein
- Lysosome membrane
- Multi-pass membrane protein
Alternative names
CYBASC3, PSEC0259, CYB561A3, Lysosomal membrane ascorbate-dependent ferrireductase CYB561A3, Cytochrome b ascorbate-dependent protein 3, Cytochrome b561 family member A3, Lysosomal cytochrome b, LCytb