CYB5R2
Function
NADH-cytochrome b5 reductases are involved in desaturation and elongation of fatty acids, cholesterol biosynthesis, drug metabolism, and, in erythrocyte, methemoglobin reduction (By similarity). Responsible for NADH-dependent lucigenin chemiluminescence in spermatozoa by reducing both lucigenin and 2-[4-iodophenyl]-3-[4-nitrophenyl]-5-[2,4-disulfophenyl]-2H tetrazolium monosodium salt (WST-1).
Sequence Similarities
Belongs to the flavoprotein pyridine nucleotide cytochrome reductase family.
Tissue Specificity
Restricted expression.
Alternative names
NADH-cytochrome b5 reductase 2, b5R.2, CYB5R2