Cyclin E1
Function
Essential for the control of the cell cycle at the G1/S (start) transition.
Post-translational modifications
Phosphorylation of both Thr-393 by GSK3 and Ser-397 by CDK2 creates a high affinity degron recognized by FBXW7, and accelerates degradation via the ubiquitin proteasome pathway. Phosphorylation at Thr-74 creates a low affinity degron also recognized by FBXW7 (By similarity).
Ubiquitinated by UHRF2; appears to occur independently of phosphorylation.
Sequence Similarities
Belongs to the cyclin family. Cyclin E subfamily.
Tissue Specificity
Found in adult spleen, and to a lesser extent in adult testis and brain.
Cellular localization
- Nucleus
Alternative names
Ccne, G1/S-specific cyclin-E1