Cyclin E2
Function
Essential for the control of the cell cycle at the late G1 and early S phase.
Post-translational modifications
Phosphorylation by CDK2 triggers its release from CDK2 and degradation via the ubiquitin proteasome pathway.
Lactylated at Lys-348 (PubMed:36896611). Delactylated by SIRT3 (PubMed:36896611).
Sequence Similarities
Belongs to the cyclin family. Cyclin E subfamily.
Tissue Specificity
According to PubMed:9858585, highest levels of expression in adult testis, thymus and brain. Lower levels in placenta, spleen and colon. Consistently elevated levels in tumor-derived cells compared to non-transformed proliferating cells. According to PubMed:9840927: low levels in thymus, prostate, brain, skeletal muscle, and kidney. Elevated levels in lung. According to PubMed:9840943 highly expressed in testis, placenta, thymus and brain. In a lesser extent in small intestine and colon.
Cellular localization
- Nucleus
Alternative names
G1/S-specific cyclin-E2, CCNE2