Cyclin-O
Developmental stage
Maximum levels during G(1) phase. Levels decrease through S and G(2) phases.
Function
Specifically required for generation of multiciliated cells, possibly by promoting a cell cycle state compatible with centriole amplification and maturation. Acts downstream of MCIDAS to promote mother centriole amplification and maturation in preparation for apical docking.
Involvement in disease
Ciliary dyskinesia, primary, 29
CILD29
A disorder characterized by abnormalities of motile cilia. Respiratory infections leading to chronic inflammation and bronchiectasis are recurrent, due to defects in the respiratory cilia. CILD29 patients do not exhibit situs inversus, a congenital abnormality in which visceral organs are opposite to their normal positions (situs solitus) due to lateral transposition.
None
The disease is caused by variants affecting the gene represented in this entry. Marked reduction of cilia in multiciliate cells due to defective mother centriole generation and placement. Remaining cilia correctly express axonemal motor proteins, are motile and do not show beating defects. Defects are probably caused by a strong reduction in the number of multiple motile cilia covering the cell surface in respiratory epithelial cells (PubMed:24747639).
Sequence Similarities
Belongs to the cyclin family.
Tissue Specificity
Present in respiratory cells (at protein level).
Cellular localization
- Cytoplasm
- Nucleus
- Nucleolus
- Localizes to the apical part of cytoplasm.
Alternative names
Cyclin-O, CCNO