CYCS

Function

Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain.

Plays a role in apoptosis. Suppression of the anti-apoptotic members or activation of the pro-apoptotic members of the Bcl-2 family leads to altered mitochondrial membrane permeability resulting in release of cytochrome c into the cytosol. Binding of cytochrome c to Apaf-1 triggers the activation of caspase-9, which then accelerates apoptosis by activating other caspases.

Involvement in disease

Thrombocytopenia 4

THC4

A form of thrombocytopenia, a hematologic disorder defined by a decrease in the number of platelets in circulating blood, resulting in the potential for increased bleeding and decreased ability for clotting.

None

The disease is caused by variants affecting the gene represented in this entry.

Post-translational modifications

Binds 1 heme group per subunit.

Phosphorylation at Tyr-49 and Tyr-98 both reduce by half the turnover in the reaction with cytochrome c oxidase, down-regulating mitochondrial respiration.

Sequence similarities

Belongs to the cytochrome c family.

Cellular localization

• Mitochondrion intermembrane space
• Loosely associated with the inner membrane.

Alternative names

• Cytochrome c
• CYCS
• CYC

Database links

• entrezGene:54205
• omim:123970
• swissprot:P99999

Target type

Proteins

Primary research area

Oncology

Other research areas

• Immunology & Infectious Disease

Molecular weight

11749Da