CYP2A6
Function
Exhibits a high coumarin 7-hydroxylase activity. Can act in the hydroxylation of the anti-cancer drugs cyclophosphamide and ifosphamide. Competent in the metabolic activation of aflatoxin B1. Constitutes the major nicotine C-oxidase. Acts as a 1,4-cineole 2-exo-monooxygenase. Possesses low phenacetin O-deethylation activity.
Sequence Similarities
Belongs to the cytochrome P450 family.
Tissue Specificity
Liver.
Cellular localization
- Endoplasmic reticulum membrane
- Peripheral membrane protein
- Microsome membrane
- Peripheral membrane protein
Alternative names
CYP2A3, CYP2A6, Cytochrome P450 2A6, CYPIIA6, Coumarin 7-hydroxylase, Cytochrome P450 IIA3, Cytochrome P450(I)