Cyp2c11
Function
A cytochrome P450 monooxygenase involved in the metabolism of steroid hormones and fatty acids. Catalyzes the hydroxylation of carbon-hydrogen bonds. Metabolizes testosterone to 2alpha- and 16alpha-hydroxytestosterone (PubMed:2434473). Catalyzes the epoxidation of double bonds of polyunsaturated fatty acids (PUFAs) (PubMed:10491410, PubMed:15766564). Converts arachidonic acid (ARA, C20:4(n-6)) primarily to epoxyeicosatrienoic acid (EET) regioisomers, 8,9-, 11,12-, and 14,15-EET, with both R,S and S,R stereochemistry (PubMed:10491410). Preferentially produces 11R,12S-EET enantiomer. To a lesser extent, catalyzes the hydroxylation of arachidonic acid producing hydroxyeicosatetraenoates (HETEs) (PubMed:10491410). Metabolizes eicosapentaenoic acid (EPA, C20:5(n-3)) to epoxyeicosatetraenoic acid (EETeTr) regioisomers, 8,9-, 11,12-, 14,15-, and 17,18-EETeTr, preferentially producing 17R,18S-EETeTr enantiomer (PubMed:15766564). Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (NADPH--hemoprotein reductase) (PubMed:15766564, PubMed:2434473).
Pathway
Lipid metabolism; arachidonate metabolism.
Steroid metabolism.
Sequence Similarities
Belongs to the cytochrome P450 family.
Tissue Specificity
Liver and kidney; male-specific.
Cellular localization
- Endoplasmic reticulum membrane
- Peripheral membrane protein
- Microsome membrane
- Peripheral membrane protein
Alternative names
Cyp2c, Cyp2c-11, Cyp2c11, Cytochrome P450 2C11, CYPIIC11, Cytochrome P-450(M-1), Cytochrome P450-UT-2, Cytochrome P450-UT-A, Cytochrome P450H