Cyp2e1
Developmental stage
Detectable in the female liver on day 1 and reaches steady state levels on days 16-20.
Function
A cytochrome P450 monooxygenase involved in the metabolism of fatty acids. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (NADPH--hemoprotein reductase). Catalyzes the hydroxylation of carbon-hydrogen bonds. Hydroxylates fatty acids specifically at the omega-1 position displaying the highest catalytic activity for saturated fatty acids. May be involved in the oxidative metabolism of xenobiotics.
Pathway
Lipid metabolism; fatty acid metabolism.
Sequence Similarities
Belongs to the cytochrome P450 family.
Tissue Specificity
Highest level in the liver and to a lesser extent in the kidney, with a higher level in the male kidney than in the female.
Cellular localization
- Endoplasmic reticulum membrane
- Peripheral membrane protein
- Microsome membrane
- Peripheral membrane protein
- Mitochondrion inner membrane
- Peripheral membrane protein
- Post-translationally targeted to mitochondria. TOMM70 is required for the translocation across the mitochondrial outer membrane. After translocation into the matrix, associates with the inner membrane as a membrane extrinsic protein.
Alternative names
Cyp2e, Cyp2e-1, Cyp2e1, Cytochrome P450 2E1, 4-nitrophenol 2-hydroxylase, CYPIIE1, Cytochrome P450-ALC, Cytochrome P450-J