CYSLTR2
Function
Receptor for cysteinyl leukotrienes. The response is mediated via a G-protein that activates a phosphatidylinositol-calcium second messenger system. Stimulation by BAY u9773, a partial agonist, induces specific contractions of pulmonary veins and might also have an indirect role in the relaxation of the pulmonary vascular endothelium. The rank order of affinities for the leukotrienes is LTC4 = LTD4 >> LTE4.
Sequence Similarities
Belongs to the G-protein coupled receptor 1 family.
Tissue Specificity
Widely expressed, with highest levels in the heart, placenta, spleen, peripheral blood leukocytes and adrenal gland. In lung, expressed in the interstitial macrophages, and slightly in smooth muscle cells.
Cellular localization
- Cell membrane
- Multi-pass membrane protein
Alternative names
CYSLT2, CYSLT2R, PSEC0146, CYSLTR2, Cysteinyl leukotriene receptor 2, CysLTR2, G-protein coupled receptor GPCR21, G-protein coupled receptor HG57, HPN321, hGPCR21