Cysteine dioxygenase type 1
Function
Catalyzes the oxidation of cysteine to cysteine sulfinic acid with addition of molecular dioxygen.
Pathway
Organosulfur biosynthesis; taurine biosynthesis; hypotaurine from L-cysteine: step 1/2.
Post-translational modifications
The thioether cross-link between Cys-93 and Tyr-157 plays a structural role through stabilizing the Fe(2+) ion, and prevents the production of highly damaging free hydroxyl radicals by holding the oxygen radical via hydroxyl hydrogen.
Sequence Similarities
Belongs to the cysteine dioxygenase family.
Tissue Specificity
Highly expressed in liver and placenta. Low expression in heart, brain and pancreas. Also detected in hepatoblastoma Hep-G2 cells.
Alternative names
Cysteine dioxygenase type 1, Cysteine dioxygenase type I, CDO, CDO-I, CDO1