CYTH1
Domain
Binds via its PH domain to the inositol head group of phosphatidylinositol 3,4,5-trisphosphate.
Autoinhibited by its C-terminal basic region.
Function
Promotes guanine-nucleotide exchange on ARF1, ARF5 and ARF6. Promotes the activation of ARF factors through replacement of GDP with GTP. Plays an important role in membrane trafficking, during junctional remodeling and epithelial polarization, through regulation of ARF6 activity.
Post-translational modifications
Ubiquitinated by SCF(FBXW11) E3 ubiquitin-protein ligase complex. Ubiquitination induces proteasomal degradation.
Tissue Specificity
Ubiquitous.
Cellular localization
- Cell membrane
- Peripheral membrane protein
- Cytoplasm
- Cytosol
- Cell junction
- Tight junction
- Cell junction
- Adherens junction
- Colocalized with TJP1 during epithelial polarization.
Alternative names
D17S811E, PSCD1, CYTH1, Cytohesin-1, SEC7 homolog B2-1