CYTH3
Domain
Binds via its PH domain to the inositol head group of phosphatidylinositol 3,4,5-trisphosphate.
Autoinhibited by its C-terminal basic region.
Function
Promotes guanine-nucleotide exchange on ARF1 and ARF6. Promotes the activation of ARF factors through replacement of GDP with GTP. Plays a role in the epithelial polarization (By similarity).
Tissue Specificity
Almost absent from liver, thymus and peripheral blood lymphocytes.
Cellular localization
- Cytoplasm
- Cytosol
- Cell membrane
- Peripheral membrane protein
- Cell junction
- Adherens junction
- Cell junction
- Tight junction
- Translocates from the cytosol to membranes enriched in phosphatidylinositol 3,4,5-trisphosphate.
Alternative names
ARNO3, GRP1, PSCD3, CYTH3, Cytohesin-3, ARF nucleotide-binding site opener 3, General receptor of phosphoinositides 1, Protein ARNO3, Grp1