CYTH4
Domain
Binds via its PH domain to the inositol head group of phosphatidylinositol 3,4,5-trisphosphate.
Autoinhibited by its C-terminal basic region.
Function
Promotes guanine-nucleotide exchange on ARF1 and ARF5. Promotes the activation of ARF factors through replacement of GDP with GTP.
Tissue Specificity
Expressed predominantly in peripheral blood leukocytes.
Cellular localization
- Cell membrane
- Peripheral membrane protein
Alternative names
CYT4, PSCD4, CYTH4, Cytohesin-4