Cytosolic 5'-nucleotidase 1A
Function
Catalyzes the hydrolysis of ribonucleotide and deoxyribonucleotide monophosphates, releasing inorganic phosphate and the corresponding nucleoside (PubMed:11133996, PubMed:34814800, PubMed:7599155, PubMed:8967393). AMP is the major substrate but can also hydrolyze dCMP and IMP (PubMed:11133996, PubMed:34814800, PubMed:7599155, PubMed:8967393).
Sequence Similarities
Belongs to the 5'-nucleotidase type 3 family.
Tissue Specificity
Highly expressed in skeletal muscle. Detected at intermediate levels in heart, brain, kidney and pancreas.
Cellular localization
- Cytoplasm
Alternative names
Cytosolic 5'-nucleotidase 1A, cN1A, 5'-deoxynucleotidase, Cytosolic 5'-nucleotidase IA, cN-I, cN-IA, NT5C1A