DAAM1
Domain
The C-terminal DAD domain may participate in intramolecular interactions with the N-terminus.
The DAD domain regulates activation via by an autoinhibitory interaction with the GBD/FH3 domain. This autoinhibition is released upon competitive binding of an activated GTPase. The release of DAD allows the FH2 domain to then nucleate and elongate nonbranched actin filaments (By similarity).
Function
Binds to disheveled (Dvl) and Rho, and mediates Wnt-induced Dvl-Rho complex formation. May play a role as a scaffolding protein to recruit Rho-GDP and Rho-GEF, thereby enhancing Rho-GTP formation. Can direct nucleation and elongation of new actin filaments. Involved in building functional cilia (PubMed:16630611, PubMed:17482208). Involved in the organization of the subapical actin network in multiciliated epithelial cells (By similarity). Together with DAAM2, required for myocardial maturation and sarcomere assembly (By similarity). During cell division, may regulate RHOA activation that signals spindle orientation and chromosomal segregation.
Sequence Similarities
Belongs to the formin homology family.
Tissue Specificity
Expressed in all tissues examined.
Cellular localization
- Cytoplasm
- Cytoplasm
- Cytoskeleton
- Cilium basal body
- Perinuclear. Colocalizes with RHOA and KANK1 around centrosomes.
Alternative names
KIAA0666, DAAM1, Disheveled-associated activator of morphogenesis 1